Sir Thomas Lauder Brunton, 1st Baronet, (14 March 1844 – 16 September 1916) was a British physician who is most-closely associated with the use of

amyl nitrite Amyl nitrite is a chemical compound with the formula C5H11ONO. A variety of isomers are known, but they all feature an amyl group attached to the nitrite functional group. The alkyl group is unreactive and the chemical and biological propertie ...

to treat

angina pectoris Angina, also known as angina pectoris, is chest pain or pressure, usually caused by insufficient blood flow to the heart muscle (myocardium). It is most commonly a symptom of coronary artery disease. Angina is typically the result of obstru ...

Early life

Brunton was born on 14 March 1844 in

Roxburgh Roxburgh () is a civil parish and formerly a royal burgh, in the historic county of Roxburghshire in the Scottish Borders, Scotland. It was an important trading burgh in High Medieval to early modern Scotland. In the Middle Ages it had at leas ...

in southeastern Scotland, the son of James Brunton (1781–1863) and his second wife Agnes Stenhouse (1807–1848). James's first wife was Euphemia Lauder (1794–1822), which gives explanation for his middle name, although he was not directly related to the Lauder's of the Bass. He studied medicine at the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...

, beginning research into pharmacology while still a student there, and receiving a gold medal for his 1866 thesis on

digitalis ''Digitalis'' ( or ) is a genus of about 20 species of herbaceous perennial plants, shrubs, and biennials, commonly called foxgloves. ''Digitalis'' is native to Europe, western Asia, and northwestern Africa. The flowers are tubular in sha ...

Career

He left Edinburgh to work in Austria, the Netherlands, and Germany, returning to

University College, London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = � ...

, and while there he was selected for a position at

St. Bartholomew's Hospital St Bartholomew's Hospital, commonly known as Barts, is a teaching hospital located in the City of London. It was founded in 1123 and is currently run by Barts Health NHS Trust. History Early history Barts was founded in 1123 by Rahere (died ...

. Brunton's clinical use of

to treat

angina Angina, also known as angina pectoris, is chest pain or pressure, usually caused by ischemia, insufficient blood flow to the Cardiac muscle, heart muscle (myocardium). It is most commonly a symptom of coronary artery disease. Angina is typical ...

was inspired by earlier work with the same reagent by

Arthur Gamgee Prof Arthur Gamgee FRS FRSE (11 October 1841 – 29 May 1909) was a British biochemist. Life Arthur Gamgee was the youngest of eight children of Joseph Gamgee, an Edinburgh-born veterinarian and pathologist and his wife Mary Ann West. He was ...

and Benjamin Ward Richardson. Brunton reasoned that the pain and discomfort of angina could be reduced by administering amyl nitrite to open the coronary arteries of patients. In 1874, Brunton was made a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

. He delivered the

Goulstonian Lecture The Goulstonian Lectures are an annual lecture series given on behalf of the Royal College of Physicians in London. They began in 1639. The lectures are named for Theodore Goulston (or Gulston, died 1632), who founded them with a bequest A beque ...

in 1877 on "Pharmacology and Therapeutics" and the

Croonian Lecture The Croonian Medal and Lecture is a prestigious award, a medal, and lecture given at the invitation of the Royal Society and the Royal College of Physicians. Among the papers of William Croone at his death in 1684, was a plan to endow a single l ...

in 1889 on "The Chemical structure of Physiological Action", both to the

Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...

. He was appointed a

Knight Bachelor The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised orders of chivalry; it is a part of the British honours system. Knights Bachelor are the ...

in the 1900 New Year Honours list, received the knighthood by

Queen Victoria Victoria (Alexandrina Victoria; 24 May 1819 – 22 January 1901) was Queen of the United Kingdom of Great Britain and Ireland from 20 June 1837 until Death and state funeral of Queen Victoria, her death in 1901. Her reign of 63 years and 21 ...

Osborne House Osborne House is a former royal residence in East Cowes, Isle of Wight, United Kingdom. The house was built between 1845 and 1851 for Queen Victoria and Prince Albert as a summer home and rural retreat. Albert designed the house himself, in t ...

on 9 February 1900, and was made a

baronet A baronet ( or ; abbreviated Bart or Bt) or the female equivalent, a baronetess (, , or ; abbreviation Btss), is the holder of a baronetcy, a hereditary title awarded by the British Crown. The title of baronet is mentioned as early as the 14th ...

in 1908. In 1915, he was awarded the

Cameron Prize for Therapeutics of the University of Edinburgh The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the College of Medicine and Veterinary Medicine to a person who has made any highly important and valuable addition to Practical Therapeutics in the previous five ye ...

Diabetes

Brunton favoured a low-carbohydrate high-fat diet to treat

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

. In 1874, he recommended a diet consisting of butcher meat, fish, eggs and soup with butter, cheese, cream and oil. All fruit and vegetables apart from cress, lettuce and spinach were forbidden. In ''

The Lancet ''The Lancet'' is a weekly peer-reviewed general medical journal and one of the oldest of its kind. It is also the world's highest-impact academic journal. It was founded in England in 1823. The journal publishes original research articles, ...

'' in 1894, Brunton stated that he was the first to use

raw meat Raw meat generally refers to any type of uncooked muscle tissue of an animal used for food. In the meat production industry, the term ‘meat’ refers specifically to mammalian flesh, while the words ‘poultry’ and ‘seafood’ are used to ...

to treat diabetic patients in 1873. The results were not successful.

Personal life

Brunton married Louisa Jane, daughter of Edward Stopford,

Archdeacon of Meath The archdeacon of Meath is a senior ecclesiastical officer within the united Diocese of Meath and Kildare. The archdeaconry can trace its history from Helias, the first known incumbent, who held the office in the twelfth century to the last dis ...

, in 1879. She died in 1909. He died in

London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...

on 16 September 1916, aged 72, and was buried on the eastern side of

Highgate Cemetery Highgate Cemetery is a place of burial in north London, England. There are approximately 170,000 people buried in around 53,000 graves across the West and East Cemeteries. Highgate Cemetery is notable both for some of the people buried there as ...

. His memorial was designed by Sir

Robert Lorimer Sir Robert Stodart Lorimer, KBE (4 November 1864 – 13 September 1929) was a prolific Scottish architect and furniture designer noted for his sensitive restorations of historic houses and castles, for new work in Scots Baronial and Gothi ...

. Lorimer also designed a plaque to Brunton in

Bowden Bowden may refer to: Places Australia * Bowden Island, one of the Family Islands in Queensland * Bowden, South Australia, northwestern suburb of Adelaide * Bowden railway station Canada * Bowden, Alberta, town in central Alberta England * Bowde ...

in Roxburghshire, erected in 1920. Family grave of Sir Thomas Lauder Brunton in Highgate Cemetery

He was succeeded in the baronetcy by his eldest son Stopford Brunton. Another son, Lt. Edward Brunton, was killed at the

Battle of Loos The Battle of Loos took place from 1915 in France on the Western Front, during the First World War. It was the biggest British attack of 1915, the first time that the British used poison gas and the first mass engagement of New Army units. Th ...

. Some of Brunton's papers are held at the National Library of Medicine.

Selected publications

* * * * * * *

References

External links

* {{DEFAULTSORT:Brunton, Thomas Lauder 1844 births 1916 deaths 19th-century Scottish medical doctors Alumni of the University of Edinburgh Baronets in the Baronetage of the United Kingdom British diabetologists Burials at Highgate Cemetery Fellows of the Royal Society Knights Bachelor Low-carbohydrate diet advocates Scottish medical writers